Talk Abstract:
There is a real urgency to better understand the complexities of Alzheimer's disease, with an aging population and no effective treatments available. Alzheimer's manifests neuropathologically by both amyloid-ß plaques and tau containing neurofibrillary tangles; however, the mechanisms by which those brain lesions initiate and drive the disease remain uncertain. In my talk, I will present data, mostly from in vivo two-photon calcium imaging in mouse models, that show how Alzheimer neuropathology causes massive impairments in neuronal circuit physiology that lead to memory problems – and that such impairments can be reversed only under certain conditions, which has important implications for clinical trials in patients.
